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The mucus is the first barrier intestinal bacteria encounter, and pathogens must penetrate it to reach epithelial cells during infection

Spatial transcriptomics sequencing According to the Franklin and Paxinos Mouse Brain Atlas (3rd edition), coronal sections were made in reference to the bregma, from 2.92 mm anterior to 3.88 mm posterior (AP: 2.92 to 3.88 mm), with a dorsoventral depth of 1.82.5 mm, and a mediolateral range of 1.2 mm from the midline

SiriwardhanaNKalupahanaNSFletcherSXinWClaycombeKJQuignard-BoulangeAet al

Meanwhile, the activity of the cysteine-glutamate transporter protein system XC- activity is inhibited, further exacerbating the process

Hengherr, S., Heyer, A

& Thykjaer, T